ChemicalBook > CAS DataBase List > (±)-erythro-(S*,S*)-1-[2,3-(Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanolhydrochloride

(±)-erythro-(S*,S*)-1-[2,3-(Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanolhydrochloride

Product Name
(±)-erythro-(S*,S*)-1-[2,3-(Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanolhydrochloride
CAS No.
72795-01-8
Chemical Name
(±)-erythro-(S*,S*)-1-[2,3-(Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanolhydrochloride
Synonyms
CS-769;ICI 118;551 hydrochloride;CI 118551 Hydrochloride;ICI 118,551 hydrochloride, >=98%;(2R,3R)-rel-1-[(2,3-Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanol hydrochloride (1:1);(±)-erythro-(S*,S*)-1-[2,3-(Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanolhydrochloride;ICI118551,ICI 118,551 hydrochloride,ICI 118551,Adrenergic Receptor,ICI-118551,Inhibitor,Beta Receptor,inhibit,ICI 118,551
CBNumber
CB32518939
Molecular Formula
C17H28ClNO2
Formula Weight
313.87
MOL File
72795-01-8.mol
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(±)-erythro-(S*,S*)-1-[2,3-(Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanolhydrochloride Property

storage temp. 
desiccated
solubility 
DMSO : 25 mg/mL (79.65 mM; Need ultrasonic)H2O : 12.5 mg/mL (39.83 mM; Need ultrasonic)
form 
powder
color 
white
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
I127
Product name
ICI 118,551 hydrochloride
Purity
≥98% (HPLC), powder
Packaging
5mg
Price
$263
Updated
2024/03/01
Sigma-Aldrich
Product number
I127
Product name
ICI 118,551 hydrochloride
Purity
≥98% (HPLC), powder
Packaging
25mg
Price
$934
Updated
2024/03/01
Cayman Chemical
Product number
15591
Product name
ICI 118551 (hydrochloride)
Purity
≥99%
Packaging
10mg
Price
$145
Updated
2024/03/01
Cayman Chemical
Product number
15591
Product name
ICI 118551 (hydrochloride)
Purity
≥99%
Packaging
50mg
Price
$616
Updated
2024/03/01
TRC
Product number
I163850
Product name
ICI 118,551 hydrochloride
Packaging
5mg
Price
$140
Updated
2021/12/16
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(±)-erythro-(S*,S*)-1-[2,3-(Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanolhydrochloride Chemical Properties,Usage,Production

Description

ICI 118551 is a potent, selective antagonist of the β2-adrenergic receptor (Ki = 0.7 nM for the β2receptor, compared with 49.5 and 611 nM for β1 and β3 receptors, respectively). It is active in vivo and is often used to evaluate the actions of adrenergic receptor agonists.

Uses

ICI 118,551 hydrochloride has been used:

  • to block β-adrenergic signaling in various experiments
  • to counteract degradation by endogenous T-lymphocyte monoamine oxidases
  • to determine the specific receptor subtype necessary for isoproterenol to induce up-regulation of gene transcripts

Uses

The (R,R)-enantiomer of ICI 118551 as highly selective β2-adrenoceptor antagonist. The S,S-enantiomer is the most potent.

Biochem/physiol Actions

ICI 118,551 has been used to treat vasomotor migraines and somatic troubles related to anxiety state.

storage

Store at RT

(±)-erythro-(S*,S*)-1-[2,3-(Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanolhydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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(±)-erythro-(S*,S*)-1-[2,3-(Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanolhydrochloride Suppliers

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72795-01-8, (±)-erythro-(S*,S*)-1-[2,3-(Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanolhydrochlorideRelated Search:

Hydrotalcite Tizanidine Tizanidine hydrochloride Carvedilol (-)-CYANOPINDOLOL HEMIFUMARATE Propranolol hydrochloride GUANFACINE HCL L-NORADRENALINE BITARTRATE Rauwolscine hydrochloride Wandonorm GUANFACINE HCL

  • (±)-erythro-(S*,S*)-1-[2,3-(Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanolhydrochloride
  • (2R,3R)-rel-1-[(2,3-Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanol hydrochloride (1:1)
  • ICI 118,551 hydrochloride, >=98%
  • CS-769
  • CI 118551 Hydrochloride
  • 551 hydrochloride
  • ICI 118
  • ICI118551,ICI 118,551 hydrochloride,ICI 118551,Adrenergic Receptor,ICI-118551,Inhibitor,Beta Receptor,inhibit,ICI 118,551
  • 72795-01-8
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